1. Nerlynx
  2. HER2+ / HR+ early breast cancer

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heading-Nerlynx-Neratinib--HER2-Breast-Cancer

HER2+ / HR+ early breast cancer

Breast cancer epidemiology

Breast cancer is the most common cancer in women, with more than 2 million new cases each year worldwide.

Amplification or overexpression of HER2 occurs in approximately 15–30% of breast cancers.15
Around 80% of breast cancers test positive for ER, with 65% of these also testing positive for PR.29
Around 10% of breast cancers are HER2+/HR+.30

Breast cancer in females by subtype (%)30 :

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eBC epidemiology

After completion of trastuzumab-based therapy, your HER2+/HR+ early breast cancer patients are still at risk of recurrence1-3,6,7,31-36

Without further treatment, 20-30% of patients with HER2+/HR+ disease will experience disease recurrence within 10 years of completing trastuzumab-based therapy. 1-3,6,7,31-36

Residual risk of recurrence for HER2+/HR+ (%) 3 years 5 years 6 years 8 years 10 years
EBCTCG meta-analysis31,a
(adjuvant trastuzumab)		 - 14 - - 20

HERA6,33,b 
(adjuvant trastuzumab)

 10 - - - 28

APHINITY32,34,35,b
(adjuvant trastuzumab + pertuzumab)

 5 - 9
11
 -
KATHERINE7,c
(post-neoadjuvant T-DM1)		 9 - -

-

 -
ExteNET control arm in HER2+/HR+ less than one year since trastuzumab therapy population1,d
(adjuvant trastuzumab)		 - 14 - - -

This table is not direct cross-trial comparisons: direct comparisons cannot be made in the absence of head-to-head trials.

DFS, disease-free survival; HER2, human epidermal growth factor receptor 2; HR+, hormone receptor positive; T-DM1, trastuzumab emtasine.
a Recurrence refers to DFS, defined as the time from enrolment to documentation of the first of any of these events: local, regional or distant recurrence of breast cancer; a new primary contralateral breast cancer.31
b Recurrence refers to DFS, defined as the time from randomisation to the first occurrence of any of these events: recurrence of breast cancer at any site; the development of ipsilateral or contralateral breast cancer, including ductal carcinoma in situ but not lobular carcinoma in situ; second non-breast malignant disease other than basal-cell or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix; or death from any cause.36
c Recurrence refers to iDFS, defined as time from randomisation to the first occurrence of any of the following events: recurrence of ipsilateral invasive breast tumour, recurrence of ipsilateral locoregional invasive breast cancer, contralateral invasive breast cancer, a distant disease recurrence or death from any cause.7,34
d Recurrence defined as the first occurrence of any of the following events: recurrence of ipsilateral invasive breast tumour, recurrence of ipsilateral locoregional invasive breast cancer, contralateral invasive breast cancer, a distant disease recurrence, or death from any cause.

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